The Australian Centre for Cancer Glycomics (A2CG)
All human cells are extensively decorated with a range of complex sugar moieties (glycans), which form the host cell glycome. These glycans are utilised as receptors for a variety of carbohydrate-recognising proteins, and the inter-cellular interactions between glycans and proteins play an essential role in how cells communicate with each other and their environment. Not surprisingly, they also play critical roles in maintaining health and in the pathogenesis of disease, including cancers. Yet, the language of glycan interactions remains poorly understood. The technology required to sequence the glycome for human clinical tissue has only recently been developed, and the A2CG is pioneering this field.
Our team of research scientists are dedicated to understanding cancer glycans and how we can exploit this knowledge to create new generation drugs, vaccines, and diagnostics.
A Call to Industry
Improving knowledge of the glycan structures present in cancer cells will lead to a better understanding of how to treat the most challenging forms of cancer. With advanced technological infrastructure, knowledge and exceptional human resource, the A2CG seeks a progressive foundational partner under a structured, 5-year program to systematically mine the cancer glycome with the goal of significantly enhancing the lives of cancer patients though this innovative and revolutionary science.
The A2CG team’s extensive expertise in analytical glycoproteomics focuses on the following clinical applications
- Diagnostic tools - Glycans as
novel diagnostic and prognostic disease markers
- Therapeutic potential - tumour-associated carbohydrate antigen (TACA) identification and translation to develop monoclonal antibodies and other drug candidate technologies
- Precision medicine - Development of specific and targeted medicines based on cancer glycan signatures
- Advanced imaging - Micro-section glycomics from histopathological tissue slides to bridge histopathology and molecular imaging
- Clinical analytics - Development of rapid, bedside diagnostic tools using focused glycomics and glycoproteomics