Modelling neurodegeneration in the zebrafish and drug discovery
This project aims at establishing new zebrafish models of motoneuron degeneration or neurodegeneration per se. We will use state-of-the-art genome editing tools (optimised CRISPR/Cas9 approach) to manipulate selected genes of interest to both validate their predicted pathogenicity and generate animals developing neurodegeneration. These models will further be used to investigate the underlying degenerative mechanisms and establish drug screening/discovery programs.
- Primary supervisor: Dr Jean Giacomotto
- Other supervisor: TBA
- To apply: Contact Dr Jean Giacomotto with your CV at j.giacomotto@griffith.edu.au
Zebrafishing for novel bioactive molecules
Whilst many current drugs are derived from nature, many more bioactive molecules have still to be discovered.
To help speed up discovery, we will develop i) a unique multipurpose zebrafish model combining different transgenic fluorescent markers/sensors and ii) automated assays to screen existing diverse chemical libraries for bioactive molecules.
Validated assays will then be used to screen natural product libraries.
- Primary supervisor: Dr Jean Giacomotto
- Other supervisor: TBA
- To apply: Contact Dr Jean Giacomotto with your CV at j.giacomotto@griffith.edu.au
Unveiling the normal and pathogenic role of neurexins in the developing brain
Neurexins are a family of genes that have been associated with several neurological diseases. We have generated a series of innovative zebrafish CRISPR-mutants that should allow to better understand the role of these genes in the developing brain. We will combine single-cell transcriptomics studies, high-end imaging, and behavioural approaches to highlight their critical function in brain development and plasticity.
- Primary supervisor: Dr Jean Giacomotto
- Other supervisor: TBA
- To apply: Contact Dr Jean Giacomotto with your CV at j.giacomotto@griffith.edu.au