BSc Hons (Applied Mathematics)
Contact details for Dr Josef Barnes: email@example.com
Mathematically Modelling the Electrophysiological Effects of Ischaemia in the Heart
This project aims to gain a deeper understanding of the electrical behaviour of the heart during ischaemia. Firstly, computer models will be used to study the effects of ischaemia on the ST segment of the ECG. Initial studies will look at simple models to gain an understanding of the fundamental characteristics which influence the electrical behaviour such as conductivity values and ischaemic shapes. Once this is achieved, realistic cardiac models will be introduced to validate earlier observations and provide results which relate to clinical situations.
The second aspect of this project is to study the electrical behaviour of ischaemic cardiac tissue during a non-steady state situation. This will be done by stimulating a section of the heart and examining the electrical propagation through the tissue. Using this idea, different sections of the ECG can be simulated and the effect of ischaemic tissue studied.
Assoc Prof Peter Johnston
Dr Owen Jepps
- Mathematical modelling of the electric field in the human heart
- Inverse problems in electrocardiology
- Numerical methods for solving differential equations
- J. P. Barnes, P. R. Johnston. The effect of the shape of ischaemic regions in the heart on the resulting extracellular epicardial potential distributions. Computing in Cardiology 2010;37