In order to develop new strategic micro- and nanotechnologies, open questions on the behaviour of very small systems need to be addressed. Micro- and nanoscale systems exhibit unique properties that cannot be predicted from the theory of large-scale systems. QMNC members have played a significant role in addressing these issues. For example, work by Dobson and Gould has shown that van der Waals interactions between systems with nanoscale dimensions have some unexpected features. Similarly, novel aspects of the theory of fluctuations in confined fluids and the response of systems to changes (such as changing the temperature or application of strain) have been developed by Jepps, B. Johnston and co-workers. Collaboration with experimentalists has allowed some of these results to be tested and others have been tested using computer simulations. Fundamental theoretical and experimental studies of molecular interactions (Brown, Hope) also allow predictions to be made on the formation of micro- and nanostructures, and these have been used to develop new strategies for applications such as fuel storage. Another field of interest (Nguyen, Gray and Dobson) involves magnetic nanoparticles and their interactions, an area with many open questions and with diverse applications in fields such as microfluidics and cancer treatment.