Professor Jennifer Martin
The world urgently needs better ways to combat ‘superbugs’ – bacteria that cause disease and are resistant to all or many drugs. In one case in January 2017, a US woman died from a ‘superbug’ infection that had spread throughout her system and could fend off 26 different antibiotics (http://www.pbs.org/newshour/rundown/superbug-resistant-every-available-antibiotic-u-s-kills-nevada-woman/)
GRIDD’s Director, Professor Jennifer Martin and her research team are investigating an innovative approach: the discovery of drugs that disarm superbugs rather than killing them.
A structural biologist, Jennifer and her team focused on understanding the actions of a key bacterial protein, DsbA, which makes up part of the ‘weapons assembly machinery’ in many harmful bacteria. Together with collaborators, her team is discovering which molecules inhibit or stop this machinery with the aim of developing these molecules into new and better antibacterials.
The work stems from a seminal paper Jennifer published 24 years ago which described the atomic resolution three-dimensional structure of this bacterial protein – a protein that turned out to be a master virulence regulator.Read more
Professor Sally-Ann Poulsen
Professor Sally-Ann Poulsen has discovered a new way to reverse multidrug resistance in cancer. Find out more on this and other research developments in Cancer.Learn more