NCNED Latest Updates and Publications
In response to a number of inquiries of this nature we are pleased to advise that we have both published papers, papers in press and additional data not for publication for confidentiality reasons.
October 18, 2016
NCNED is pleased to release the following update of world first discoveries this year in CFS/ME:
- NCNED discovered significant associations of transient receptor potential (TRP) ion channel families from CFS/ME patients.
- NCNED discovered significant reductions in TRPM3 receptors on the cell surface of natural killer (NK) cells and B cells from CFS/ME patients.
- NCNED discovered significant reductions in intracellular calcium as well as stored calcium in NK cells from CFS/ME patients.
- NCNED discovered significant changes in intracellular calcium-regulated genes from NK cells as well as cell signalling changes that are important for NK cell function and cytokine production in CFS/ME patients.
- NCNED aimed to determine if all these changes in NK cells were due to dysfunction of the TRPM3 receptors located on the cell surface of these cells.
- NCNED now reports that the significant reduction in NK activity as well as changes in intracellular signalling is associated with low intracellular calcium ions in NK cells through the impairment of TRPM3 ion channels.
- NCNED highlights these significant findings as the inability to allow sufficient calcium ions to move inside the cell with dysfunctional TRPM3 receptors.
- Importantly the significant dysregulation of TRPM3 receptors NCNED has identified is not confined to NK cells. TRPM3 receptors are located on nearly all cells in the body. The dysfunction of TRPM3 NCNED has identified suggests this receptor is involved in CFS/ME pathology.
We thank every participant, donors, the Stafford Fox Medical Research Foundation, Mr Douglas Stutt, the Alison Hunter Memorial Foundation, the Queensland Government, the Mason Foundation and Change for ME.
Without your support these pivotal studies would not have been possible.
We are continuing to explore every possible pathway for successful therapeutic interventions.
As our research continues we would also like to announce our latest published paper below.
Nguyen T, Johnston S, Clarke L, Smith P, Staines D, Marshall-Gradisnik S: Calcium mobilisation in natural killer cells from Chronic fatigue syndrome/Myalgic encephalomyelitis patients is associated with transient receptor potential melastatin 3 ion channels. Clin Exp Immunol 2016.
September 19, 2016
The National Centre for Neuroimmunology and Emerging Disease is happy to share with you our latest newsletter. This newsletter outlines our research since the last addition as well as some exciting new additions to our team. The full newsletter can be accessed by clicking on the link below.
Kind Regards and Best Wishes,
The NCNED Team
August 29, 2016
The National Centre for Neuroimmunology and Emerging Diseases (NCNED) would like to sincerely thank the Stafford Fox Medical Research Foundation, Change for ME Australia, The Alison Hunter Memorial Foundation, Mr Douglas Stutt and the Queensland Government for providing financial support for our latest publication.
This current paper reports novel results of far reaching importance for CFS/ME diagnosis and possible pathology. The paper describes world first discoveries of kinase gene dysregulation associated with changes in calcium ion function. This research leads from previous significant papers we have recently published involving research into calcium ion channels in CFS/ME. Please refer to two of our recent publications reported in Biological Research and Clinical Application of Genetics.
These publications reflect the commitment of our team in achieving the best possible outcomes for those with CFS/ME.
Sonya, Don and the NCNED Team
August 1, 2016
The co-directors of the National Centre for Neuroimmunology and Emerging Diseases, Professors Sonya Marshall-Gradisnik and Don Staines will be conducting a seminar in Sydney on August 12 from 1pm at the St George Hospital Education Centre. The seminar is suitable for both medical professionals and patients and is free and open to the public.
The seminar is hosted by the ME/CFS & FM Association of NSW Inc.
For more information, please click on the link below.
July 1, 2016
The NCNED team will have members participating in the Gold Coast Airport Marathon event, being held this weekend on the 2nd and 3rd of July. We do this as we know many of our supporters cannot.
If you would like to donate to support our research, the details on how to do so can be found by clicking the link below.
The NCNED Team
June 20, 2016
After a significant amount of hard work from the team, we are again exciting to share our latest publication with you. Even with all our hard work, this research would not be possible without the assistance of our many supporters and for that NCNED sends thank you to you all. The article may be accessed via the link below.
Huth TK, Brenu EW, Staines DR, Marshall-Gradisnik SM: Killer Cell Immunoglobulin-like Receptor Genotype and Haplotype Investigation of Natural Killer Cells from an Australian Population of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. Gene Regulation and Systems Biology 2016, 10:43-49.
June 1, 2016
Today, NCNED published an important paper reporting a significant reduction in TRPM3 cell surface expression in NK and B lymphocytes, as well as decreased intracellular calcium within these cell types. As this receptor is located on almost all human cells and tissues, this raises the question as to whether similar changes of TRPM3 expression or function of these receptors promotes more widespread disruption of intracellular signalling homeostasis in CFS/ME patients.
This paper is an important finding. We thank every one of our donors and participants for supporting us.
Sonya, Don and the NCNED TeamNguyen T, Staines D, Nilius B, Smith P, Marshall-Gradisnik S: Novel identification and characterisation of Transient receptor potential melastatin 3 ion channels on Natural Killer cells and B lymphocytes: effects on cell signalling in Chronic fatigue syndrome/Myalgic encephalomyelitis patients. Biological Research 2016, 49(1):1-8.
May 26, 2016
NCNED would like to sent a great thank you to all our sponsors, donors and participants of our research. Without your support, our research here would not be possible.
As a result of this support, May has been a big month for us here at NCNED with another paper published. This paper reviews the existing evidence on drug therapies with an aim to determine whether any can be recommended for patients for CFS/ME. The full paper may be accessed by clicking on the link below.
May 19, 2016
The NCNED Team is excited to announce the publication of another research article titled “Epidemiological characteristics of chronic fatigue-syndrome/myalgic encephalomyelitis in Australian patients”. This research published in this article would not be possible without the many people taking part in our research studies. Thank you to all who have participated and supported the group. You may access the article by clicking on the link below.
May 12, 2016
International ME/CFS & FM Awareness Day
Today is May 12, which is also International CFS/ME & FM Awareness Day. In addition to the team gathering together to mark the occasion, NCNED has also lit the Griffith Health Centre at the Gold Coast up in blue to help raise awareness of these illnesses. The NCNED team would also like to send a sincere thank you to all the supporters and participants who have assisted us in our research.
May 9, 2016
Thursday May 12, 2016 marks International ME/CFS and FM awareness day. To help celebrate the occasion, the team here at NCNED has taken some time out of their busy research schedule to share the following photo.
April 22, 2016
NCNED is pleased to announce the release of our latest publication entitled “ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.”
This paper identifies pathological changes in vital signalling pathways in ME/CFS. These pathways exert a major influence over cell functioning suggesting important fundamental steps in the development of the pathomechanism of ME/CFS. The full article can be accessed by following the link below.
We sincerely thank all of our supporters including the Stafford Fox Foundation, Alison Hunter Memorial Foundation, the Mason Foundation, the Queensland Government and all participants who have contributed to this important research outcome.
Huth TK, Staines D, Marshall-Gradisnik S: ERK1/2, MEK1/2 and p38 downstream signalling molecules impaired in CD56dimCD16+ and CD56brightCD16dim/− natural killer cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. Journal of Translational Medicine 2016, 14(1):1-10.
There are more publications to come.
April 5, 2016
The team at NCNED would like to sincerely thank all participants in our research. The research we do and discoveries we make would not be possible without your support. As a research institution, the data we collect is currently used for research purposes only and is not accompanied by typical references ranges required to be interpreted clinically. Depending on which study they are involved in, participants in our research may receive some results after their visit and NCNED has received special authorisation to do so, however some results we are not able to release due to the above reasons and strict national ethical regulations the team must follow.
The NCNED team has had a number of publications released in late 2015 and also early in 2016. There are a number of publications still to come with additional papers in the pipeline. These scientific publications contain the research data collected from your participation. Your participation makes a difference as we hope this information will eventually be used in mainstream clinical settings to assist with diagnosis of CFS/ME.
April 1, 2016
NCNED has again had a scientific research paper published. The article, which was published in the journal The Application of Clinical Genetics, may be accessed using the following link. As with all the work at NCNED, this would not be possible without the generous support of our participants.
Marshall-Gradisnik S, Huth T, Chacko A, Johnston S, Smith P, Staines D: Natural killer cells and single nucleotide polymorphisms of specific ion channels and receptor genes in myalgic encephalomyelitis/chronic fatigue syndrome. The Application of Clinical Genetics 2016, 9:39-47.
March 29, 2016
The team at NCNED would again like announce their latest scientific paper that has been accepted for publication. We would like to thank all the supporters and participants who assist us in our research. The abstract for this paper may be accessed by clicking the link below.
Ramos S, Brenu E, Broadley S, Kwiatek R, Ng J, Nguyen T, Freeman S, Staines D, Marshall-Gradisnik S: Regulatory T, natural killer T and gammadelta T cells in multiple sclerosis and chronic fatigue syndrome/myalgic encephalomyelitis: a comparison. Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand 2016.
March 1, 2016
In an interview with the ABC, Professor Marshall-Gradisnik, Professor Staines and Lyn Wilson, a CFS/ME patient discussed the NCNED team’s breakthrough study. This study found specific markers on white blood cells that has the potential to be used help screen and diagnose patients with CFS/ME using blood test. The team is currently looking to partner with diagnostic companies to develop and bring the test to fruition. This test has the potential to expedite the diagnostic process, bring recognition to the illness, and drive new research into possible interventions.
February 15, 2016
The NCNED team is again proud to announce our latest publication. These publications are impossible without the participants who take part of our research as well as the hardworking team of reseachers. The publication may be accessed by clicking on the reference details below.
Marshall-Gradisnik SM, Chacko A, Johnston S, Smith P, Nilius B, Staines DR: Genotype Frequencies of Transient Receptor Potential Melastatin M3 Ion Channels and Acetylcholine Muscarinic M3 Receptor Gene Polymorphisms in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. Immunology and Immunogenetics Insights 2016, 8, 1-2
February 3, 2016
The NCNED team would like to thank the followers, supporters and patients of the CFS/ME clinic. The clinic is not accepting referrals or booking appointments at this time. The team is working incredibly hard to consolidate research and move towards developing a screening test. Our aim is always to deliver the best outcomes for patients and we hope to resume later in 2016.
January 11, 2016
The NCNED Team would like to welcome all our followers and supporters into the new year. The team is back at work and have already had their first paper published. The full details of the publication can be found below, and you can also follow the link for a full copy of the paper.
Brenu EW, Broadley S, Nguyen T, Johnston S, Ramos S, Staines D, Marshall-Gradisnik S: A Preliminary Comparative Assessment of the Role of CD8+ T Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis. Journal of Immunology Research 2016, 2016:8
November 4, 2015
Another scientific publication has successfully been released by the NCNED team titled “Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis” and published in the Scandinavian Journal of Immunology. This article can be accessed by click on the link below.
Huth TK, Brenu EW, Ramos S, Nguyen T, Broadley S, Staines D, Marshall-Gradisnik S: Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis. Scand J Immunol 2015.
November 2, 2015
NCNED is is happy to announce another successful journal publication. This paper reports on the differences in serum immune protein levels between severely affected and moderately affected CFS/ME patient groups, and was published in the International Journal of Medical Sciences. This is the first study to show that cytokine variations are associated with the severity of the illness. The article can be accessed by clicking on the link below.
Hardcastle, S.L., Brenu, E.W., Johnston, S., Nguyen, T., Huth, T., Ramos, S., Staines, D., Marshall-Gradisnik, S., Serum Immune Proteins in Moderate and Severe Chronic Fatigue Syndrome/Myalgic Encephalomyelitis Patients. International journal of medical sciences 2015 12, 764-772.
October 30, 2015
The National Centre for Neuroimmunology and Emerging Diseases has recently released a new newsletter. This newsletter contains some recent updates concerning publications and presentations, and introduction to new members of the NCNED team and a big thank you for 'Change for ME' among other news.
The newsletter can be accessed by clicking here.
October 13, 2015
Another set of congratulations are in order for the NCNED team for the acceptance of a recent paper to be published in the Journal of Translational Medicine. This data is the results of work by various members of the team over a number of years.
Hardcastle S, Brenu E, Johnston S, Nguyen T, Huth T, Ramos S, Staines D, Marshall-Gradisnik S: Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients. Journal of Translational Medicine 2015, 13(1):299.
We would like to thank everyone for their continuing interest and support of the CFS/ME Specialised Clinic. It has been a busy 9 months since the first patients attended in October last year when we officially opened the clinic for a trial period. We would like to thank you for your patience and understanding over the months leading up to your appointments.
Regrettably due to the high demand and limited spaces for appointments we are unable to take any more new patients at this time.
We always thank the participants of our studies, but our research would also not be possible without the hard work and determination of our researchers. We would like to bring your attention to Teilah Huth who has been investigating the role of Natural Killer (NK) cells in CFS/ME for a number of years as part of her doctorate degree.
NK cells belong to the innate immune system which means that they are an immune cell activated at the start of an infection. In CFS/ME patients, the function of NK cells has been found to be reduced, but we currently don’t know why and this is something Teilah is trying to find out.
Teilah has recently presented her work at NK2015 – 15th Meeting of the Society for Natural Immunity with her presentation titled “Cytotoxic Natural Killer Cell Mechanisms in CFS/ME and Multiple Sclerosis”. Teilah, along with her poster presenting her research can be seen below.
We are excited to announce that yet another recently scientific paper has been published from the National Centre for Neuroimmunology and Emerging Diseases. This paper investigates differences in the immune function of CFS/ME affected participants with varied symptom severity. The full article can be accessed by clicking on the reference details below.
Hardcastle S, Brenu E, Johnston S, Nguyen T, Huth T, Wong N, Ramos S, Staines D, Marshall-Gradisnik S: Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). BMC Immunology 2015, 16.
The National Centre of Neuroimmunology and Emerging Diseases would like to share one our our new publications. This paper investigates the relationship between Single Nucleotide Polymorphisms in Acetylcholine Receptors and CFS/ME. Clicking on the citation information below will lead you to the journal website where you can download the paper.
Marshall-Gradisnik S, Smith P, Nilius B, Staines DR: Examination of Single Nucleotide Polymorphisms in Acetylcholine Receptors in Chronic Fatigue Syndrome Patients. Immunology and Immunogenetics Insights 2015, 7:7-20.
May 11, 2015 marks the start of International M.E. Awareness Week and to help raise awareness for ME and CFS, the Griffith Health Centre at Griffith University Gold Coast was lit up in blue. Please note that the lasers shine "Team M.E @ G.U". It is just below the Griffith University Logo. Griffith University has also published a press release highlighting the importance of the occasion and the research being conducted here at NCNED. The press release can be accessed using this link.
The start of this significant week also coincides with the release of our latest paper. This is the first of a number of papers to be released by the NCNED Team in the near future. To access the article, please click here.
Marshall-Gradisnik SM, Smith P, Brenu EW, Nilius B, Ramos SB, Staines DR: Examination of Single Nucleotide Polymorphisms (SNPs) in Transient Receptor Potential (TRP) Ion Channels in Chronic Fatigue Syndrome Patients. Immunology and Immunogenetics Insights 2015, 7:1-6.
Our mission is to perform world class biomedical research that will contribute to the understanding, diagnosis and treatment of Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS) through the identification of physiological mechanisms and biomarkers.
§ To be recognised for world-class clinical and population based health and medical research.
§ To collaborate with local, national and international research institutes and researchers.
§ To translate research into preventative medicine, social and clinical care and public health outcomes.
§ To create sustained improvements in health and health care for individuals with CFS/ME.
Currently Recruiting for Studies
NCNED is actively recruiting participants for a number of studies. The first study of the year will involve the investigation of parts of the digestive tract of people with CFS and will begin in March. We are trying to find potential participants who:
1. Have been diagnosed with CFS/ME
2. Have previously undergone an intestinal biopsy procedure at the Gold Coast University Hospital.
If eligible, participants would be asked to read over the Participant Information Sheet and decide whether to consent to the use of their tissue samples for this study.
Please note we do not require any participants to undergo new biopsies for use in this study.
Multiple studies will be undertaken throughout the year. We will be contacting past participants to invite them to continue their involvement and we also welcome new participants. If you or someone you know is interested in becoming involved or if you would like more information, please contact us on firstname.lastname@example.org.
Studies for 2015 are currently planned to consist of two time periods and locations. The first is planned to commence mid-year and will be conducted in the areas between Tweed Heads and Brisbane. The second is aimed to start in October and be located in Sydney and Melbourne.
Any volunteers would be greatly appreciated. If you or someone you know match the above criteria (both points 1 and 2), please contact us on email@example.com or (07) 5678 9283.
The response to the opening of the CFS/ME specialised clinic has been fantastic!
We realise some people may be experiencing difficulty in calling through.
Due to the high volume of incoming calls to the clinic the phone line has been constantly busy and our receptionist understands this may be frustrating to those who have been unable to get through.
We ask that you please keep trying as every call is important to us!
This also effects the time it takes to respond to phone messages left by patients and our receptionist is responding to every message in as timely a manner as possible.
We would like to thank you all for your support, understanding and patience during this exciting time.
§ To make an appointment, please call 1800 188 295 and DIAL 5 when prompted.
§ Contact hours for the clinic are 8am - 4pm, Thursdays and Fridays only.
§ This is the only number to make an appointment. Please don't use any other number to make an appointment.
§ You must have a referral from your GP in order to make an appointment.
§ You can contact the clinic via email using: firstname.lastname@example.org
§ All clinic inquiries must be directed through this email.
§ The clinic operates once a week on Fridays, 9am - 3pm.
Please click on the Clinic tab to the left or use this link for more information.