Dr Jennifer Wilson

BSc (H), PhD

Research Leader and Senior Lecturer, Institute for Glycomics

Contact details for Dr Jennifer Wilson

Research Interests

• The application of biomolecular NMR to structure-based drug design
• Protein:carbohydrate interactions
• NMR structure-based drug design of potential sialidase and trans-sialidase inhibitors
• The role of sialic acid recognizing proteins in disease processes
• Investigations of hylauronan as a drug delivery vehicle for cytotoxic drugs used to treat breast cancer and the development of multivalent hyaluronan derivative therapeutics
• Components of Campylobacter chemotaxis pathway as pathogenicity determinants and future targets for novel antimicrobials using structure based drug design
• ¹H and ³¹P NMR spectroscopy of human temporal lobe abnormalities in intractable partial epilepsy
  

Publications

• Wilson JC, Hitchen PG, Frank M, Peak IR, Collins P, Morris H, Dell A and Grice ID. (2005). Identication of a capsular polysaccharide from Moraxella bovis. Carbohydr Res 340(4): 765-769.
• Albouz-Abo S, Turton R, Wilson JC and von Itzstein M. (2005). An investigation of the activity of recombinant rat skeletal muscle cytosolic sialidase. FEBS Letters 579: 1034-1038.
• Haselhorst T, Wilson JC, Thomson RJ, McAtamney S, Menting JG, Coppel RL and von Itzstein M. (2004). Saturation transfer difference (STD) ¹H-NMR experiments and in silico docking experiments to probe the binding of N-acetylneuraminic acid and derivatives to Vibrio cholerae sialidase. Proteins 56(2): 346-53.
• Haselhorst T, Wilson JC, Liakatos A, Kiefel MJ, Dyason JC and von Itzstein M. (2004). NMR spectroscopic and molecular modeling investigations of the trans-sialidase from Trypanosoma cruzi. Glycobiology 14(10): 895-907.
• Moustafa I, Connaris H, Taylor M, Zaitsev V, Wilson JC, Kiefel MJ, von Itzstein M and Taylor G. (2004). Sialic acid recognition by Vibro cholerae neuraminidase. Journal of Biological Chemistry 279: 40819-40826.