Griffith University

Professor, School of Biomolecular and Physical Sciences

Contact details for Professor Alan Mackay-Sim

Professional page for Professor Alan Mackay-Sim

Research Expertise

• Parkinson's disease
• Adult Stem Cells
• Spinal Cord Injury
• Brain development
• Repair of nervous system
• Schizophrenia
• Sense of smell

Publications

• Mackay-Sim A, Laing DG (1980) Discrimination of stressed rat odors by non-stressed rats. Physiology and Behavior. 24:699-704. (41 citations, 10 times in last 3 years)
• Mackay-Sim A, Laing DG (1981) Rat's responses to stress odors from blood and to stress odors from live animals. Physiology and Behavior. 27:503-510. (22 citations, 3 times in last 3 years)
• Mackay-Sim A, Laing DG (1981) The sources of odors from stressed rats. Physiology and Behavior. 27:511-513. (20 citations, 4 times in last 3 years)
• Mackay-Sim A, Kubie JL (1981) The salamander nose: a model system for the study of spatial coding of olfactory quality. Chemical Senses 6:249-257. (32 citations, 1 time in last 3 years)
• Sefton AJ, Mackay-Sim A, Bauer LA, Cottee LJ (1981) Cortical projections to visual centres in the rat: an HRP study. Brain Research. 215:1-14. (99 citations, 1 time in last 3 years)
• Mackay-Sim A, Shaman P, Moulton DG (1982) Topographic coding of olfactory quality: patterns of epithelial responsivity in the salamander. Journal of Neurophysiology. 48:584-596. (120 citations, 6 times in last 3 years)
• Mackay-Sim A, Sefton AJ, Martin P (1983) Subcortical projections to lateral geniculate and thalamic reticular nuclei in the hooded rat. Journal of Comparative Neurology. 213:24-36. (116 citations, 2 times in last 3 years)
• Mackay-Sim A, Nathan MH (1984) The projection from the olfactory epithelium to the olfactory bulb in the salamander, Ambystoma tigrinum. Anatomy and Embryology. 170:93-97. (30 citations, 2 times in last 3 years)
• Mackay-Sim A, Patel U (1984) Regional differences in cell genesis in the olfactory epithelium of the salamander, Ambystoma tigrinum. Experimental Brain Research. 57:99-106. (24 citations, 2 times in last 3 years)
• Mackay-Sim A, Shaman P (1984) Topographic coding of odorant quality is maintained at different concentrations in the salamander olfactory epithelium. Brain Research. 297:207-217. (29 citations, 2 times in last 3 years)
• French CR, Sefton AJ, Mackay-Sim A (1985) The inhibitory role of the visually responsive region of the thalamic reticular nucleus in the rat. Experimental Brain Research. 57:471-479. (31 citations, 1 time in last 3 years)
• Mackay-Sim A, Duvall D, Graves BM (1985) The West Indian Manatee (Trichechus manatus) lacks a vomeronasal organ. Brain Behavior and Evolution. 27:186-194. (7 citations, 2 times in last 3 years, 1 time in last 3 years)
• Mackay-Sim A, Rose JD (1986) Removal of the vomeronasal organ impairs lordosis in female hamsters: effect is reversed by luteinising hormone-releasing hormone. Neuroendocrinology 42:489-493. (28 citations, 5 times in last 3 years)
• Beard MD, Mackay-Sim A (1987) Loss of sense of smell in adult hypothyroid mice. Developmental Brain Research. 36:181-189. (12 citations)
• Lande IS de la, Parker DA S., Proctor CH, Marino V, Mackay-Sim A (1987) Cocaine inhibits extraneuronal o-methylation of exogenous norepinephrine in nasal and oral tissues of the rabbit. Life Science. 41:2463-2468. (6 citations)
• Mackay-Sim A, Beard MD (1987) Hypothyroidism disrupts neural development in the olfactory epithelium of adult mice. Developmental Brain Research. 36:190-198. (33 citations, 1 time in last 3 years)
• Panhuber H, Mackay-Sim A, Laing DG (1987) Prolonged odour exposure causes cell shrinkage in the adult rat olfactory bulb. Developmental Brain Research. 31:307-311. (10 citations)
• Mackay-Sim A, Breipohl W, Kremer M (1988) Cell dynamics in the olfactory epithelium of the salamander: a morphometric analysis. Experimental Brain Research. 71:189-198. (23 citations, 2 times in last 3 years)
• Mackay-Sim A, Dreosti I (1989) Olfactory function in zinc deficient adult mice. Experimental Brain Research. 76:207-212. (7 citations, 1 time in last 3 years)
• Mackay-Sim A (1991) Development of a "bionic nose". Genetic Engineering and Biotechnology 11(2): 11-13.
• Mackay-Sim A, Kittel P (1991) Cell dynamics in the adult mouse olfactory epithelium: a quantitative autoradiographic study. Journal of Neuroscience. 11:979-984. (115 citations, 25 times in last 3 years)
• Mackay-Sim A, Kittel P (1991) On the life span of olfactory receptor neurones. European Journal of Neuroscience. 3:209-215. (76 citations, 18 in last 3 years)
• Mackay-Sim A, Kennedy TR, Bushell GR, Thiel DV (1993) Sources of variability arising in piezoelectric odorant sensors. Analyst 118:1393-1398. (7 citations)
• Deveza R, Russell A, Thiel D, Mackay-Sim A (1994) Odour sensing for robot guidance. International Journal of Robotics Research. 13:232-239. (15 citations)
• Mackay-Sim A, Kesteven S (1994) Topographic patterns of responsiveness to odorants in the rat olfactory epithelium. Journal of Neurophysiology. 71:150-160. (57 citations, 4 times in last 3 years)
• James D, Thiel D, Bushell G, Busfield K, Mackay-Sim A (1994) Phase change and viscosity effects on a quartz crystal microbalance. Analyst, 119:2005-2007. (8 citations)
• Delay RJ, Mackay-Sim A, Roper SD (1994) Membrane properties of two types of basal cells in Necturus taste buds. Journal of Neuroscience. 14: 6132-6143. (10 citations)
• Saunders BW, Thiel DV, Mackay-Sim A (1995) Response kinetics of chemically-modified quartz piezoelectric crystals during odorant stimulation. Analyst , 120:1013-1018. (18 citations)
• Saunders BW, Thiel DV, Mackay-Sim A (1995) Olfactory imaging: an electronic nose using tiered artificial neural networks and quartz piezoelectric gas sensors. Australian Journal of Intelligent Information Processing Systems, 2:1-8.
• Brosvic GM, Risser JM, Mackay-Sim A, Doty RL (1996) Odor detection performance in hypothyroid and euthyroid rats: a signal detection analysis. Physiology and Behavior, 59:117-121.
• Mackay-Sim A, Delay RJ, Roper S, Kinnamon SC (1996) Development of voltage-dependent currents in taste receptor cells. Journal of Comparative Neurology 365:278-288. (12 citations, 1 time in last 3 years)
• MacDonald KPA, Murrell WG, Bartlett P, Bushell GR, Mackay-Sim A (1996) FGF2 promotes neuronal differentiation in explant cultures of adult and embryonic mouse olfactory epithelium. Journal of Neuroscience Research 44:27-39. (29 citations, 5 times in last 3 years)
• MacDonald KPA, Mackay-Sim A, Bushell GR, Bartlett PF (1996) Olfactory neuronal cell lines generated by retroviral insertion of the n-myc oncogene display different developmental phenotypes. Journal of Neuroscience Research 45:237-247. (20 citations, 2 times in last 3 years)
• Murrell W, Bushell GR, Livesey J, McGrath J, MacDonald KPA, Bates PR, Mackay-Sim A (1996) Neurogenesis in adult human. NeuroReport 7:1189-1194. (29 citations, 9 times in last 3 years)
• Ogura T, Mackay-Sim A, Kinnamon SC (1997) Bitter taste transduction of denatonium in the mudpuppy, Necturus maculosus. Journal of Neuroscience 17:3580-3587. (32 citations, 5 times in last 3 years)
• Féron F, Perry C, McGrath JJ, Mackay-Sim A (1998) New techniques for biopsy and culture of human olfactory epithelial neurons. Archives of Otolaryngology Head and Neck Surgery 124:861-866. (51 citations, 29 in last 3 years)
• Féron F, Mackay-Sim A, Andrieu JL, Matthaei K, Holley A, Sicard G (1999) Stress induces neurogenesis in non-neuronal cell cultures of adult olfactory epithelium. Neuroscience 88:5271-5283. (21 citations, 8 times in last 3 years)
• Féron F, Perry C, Hirning M, McGrath J and Mackay-Sim A (1999) Altered adhesion, proliferation and death in neural cultures from adults with schizophrenia. Schizophrenia Research 40:211-217. (19 citations, 9 in last 3 years)
• Féron F, Vincent A and Mackay-Sim A (1999) Dopamine promotes differentiation of olfactory neuron in vitro. Brain Research 845:252-259. (10 citations)
• Mackay-Sim A and Chuah I (2000) Neurotrophic growth factors in the primary olfactory pathway. Progress in Neurobiology 62:527-553. (44 citations)
• Newman M, Féron F and Mackay-Sim A (2000) Growth factor control of olfactory neurogenesis. Neuroscience 99:343-350. (30 citations)
• Lu J, Féron F, Ho SM, Mackay-Sim A and Waite PME (2001) Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Brain Research 889:344-357. (68 citations)
• Hsu P-E, Yu F, Féron F, Pickles JO, Sneesby K and Mackay-Sim A (2001) Basic fibroblast growth factor and fibroblast growth factor receptors in adult olfactory epithelium. Brain Research 896:188-97. (14 citations)
• McGrath JJ, Féron F, Eyles D and Mackay-Sim A (2001) Vitamin D: the neglected neurosteroid? Trends in Neuroscience 24:570-571. (13 citations)
• Mackay-Sim A and Doty RL (2001) The University of Pennsylvania Smell Identification Test: normative adjustment for Australian subjects. Australian Journal of Otolaryngology 4:174-177.
• Lu J, Féron F, Mackay-Sim A and Waite PME (2002) Olfactory ensheathing cells promote locomotor recovery after delayed transplantation into transected spinal cord. Brain 125: 14-21. (87 citations)
• Perry C, Mackay-Sim A, Féron F and McGrath J (2002) Olfactory neural cells: an untapped diagnostic and therapeutic resource. Laryngoscope 112:603-607. (5 citations)
• Wallwork B, Coman WB, Féron F, Mackay-Sim A and Cervin A (2002) Clarithromycin and prednisolone inhibit cytokine production in chronic rhinosinusitis. Laryngoscope 112:1827-1830. (14 citations)
• Eyles D, Brown J, Mackay-Sim A, McGrath J, Féron F (2003) Vitamin D3 and brain development. Neuroscience 118:641-653. (30 citations)
• Korsgren M, Erjefält JS, Hinterhölzl J, Fischer-Colbrie R, Ahlström Emanuelsson C, Andersson M, Persson CGA, Mackay-Sim A, Sundler F, Greiff L (2003) Neural expression and lavage fluid levels of secretoneurin in seasonal allergic rhinitis. American Journal of Respiratory and Critical Care Medicine 167:1504-8. (6 citations)
• Mackay-Sim A (2003) Stem cells: a beginner's guide. Social Alternatives. 22:27-33.
• McGrath JJ, Féron F, Burne TH, Mackay-Sim A, Eyles, DW (2003) The neurodevelopmental hypothesis of schizophrenia: a review of recent developments. Annals of Medicine 35:86-93. (24 citations)
• Bianco JI, Perry C, Harkin DG, Mackay-Sim A, and Féron F (2004) Neurotrophin 3 promotes purification and proliferation of olfactory ensheathing cells from human nose. Glia 45: 111-23. (11 citations)
• McLean D, Féron F, Mackay-Sim A, McCurdy R, Hirning M, Chant D, McGrath J (2004) Paradoxical association between smoking and olfactory identification in psychosis versus controls. Australian and New Zealand Journal of Psychiatry 38: 81-3. (1 citation)
• Wallwork B, Coman WB, Mackay-Sim A, Cervin A (2004) Effect of clarithromycin on nuclear factor-kappa B and transforming growth factor-beta in chronic rhinosinusitis. Laryngoscope 114:286-90. (7 citations)
• Mackay-Sim A, Féron F, Eyles D, Burne TH, McGrath J (2004) Schizophrenia, vitamin D and brain development. International Review of Neurobiology 59:351-380. (6 citations)
• McGrath J, Féron F, Burne TH, Mackay-Sim A, Eyles D (2004) Vitamin D3 - implications for brain development. Journal of Steroid Biochemistry and Molecular Biology, 89-90:557-560. (8 citations)
• Burne THJ, Féron F, Brown J, Eyles DW, McGrath JJ, Mackay-Sim A (2004) Combined prenatal and chronic postnatal vitamin D deficiency in rats impairs prepulse inhibition of startle. Physiology and Behaviour 81:651-655. (4 citations)
• Burne THJ, Becker A, Brown J, Eyles DW, Mackay-Sim A, McGrath J Transient prenatal vitamin D deficiency is associated with hyperlocomotion in adult rats. (2004) Behavioural Brain Research 154:549-555. (5 citations)
• Mackay-Sim A, Grant L, Owen C, Chant D, Silburn P (2004) Australian norms for a quantitative olfactory function test. Journal of Clinical Neuroscience 11:874-879. (2 citations)
• Burne THJ, McGrath JJ, Eyles D, Mackay-Sim A (2005) Behavioural characterization of vitamin D receptor knockout mice. Behavioural Brain Research 157:299-308. (7 citations)
• Korsgren M, Fischer-Colbrie R, , Andersson M, Coman WB, Mackay-Sim A, Persson CG, Sundler F, Wallwork B, Greiff L (2005) Secretoneurin is released into human airways by topical histamine but not capsaicin. Allergy 60:459-463.
• Féron F, Burne TJH, Brown J, Smith E, McGrath J, Mackay-Sim A, Eyles DW (2005) Developmental vitamin D deficiency alters the adult rat brain. Brain Research Bulletin 65:141-8. (5 citations)
• Mackay-Sim A (2005) Olfactory ensheathing cells and spinal cord repair. Keio J Med 54:8-14.
• Murrell W, Féron F, Wetzig A, Bianco J, Perry C, Lee G, Mackay-Sim A (2005) Multipotent stem cell in adult olfactory mucosa Developmental Dynamics 233:496-515. (9 citations)
• Haxel BR, Murrell WG, Mackay-Sim A (2005) Studies of the olfactory epithelium in anosmic patients after head trauma HNO. 53(8):682-6, 688-9. German.
• Ko P, Eyles D, Burne T, Mackay-Sim A, McGrath J (2005) Season of birth and risk of brain tumors in adults. Neurology 64:1317. (Comment)
• McCurdy RD, Féron F, McGrath JJ, Mackay-Sim A (2005) Regulation of adult olfactory neurogenesis by insulin-like growth factor-I. European Journal of Neuroscience 22:1581-1588. Front Cover (1 citation)
• Féron F, Perry C, Cochrane J, Licina P, Nowitzke A, Uquhart S, Geraghty T, Mackay-Sim A (2005) Autologous olfactory ensheathing cell transplantation in human spinal cord injury. Brain 128:2951-2960. Front Cover (5 citations)
• McCurdy R, Feron F, Perry C, Chant D, McLean D, McGrath JJ, Mackay-Sim A (2006) Cell cycle alterations in biopsied olfactory neuroepithelium in schizophrenia and bipolar I disorder using cell culture and gene expression analyses. Schizophrenia Research 82:163-173.
• Wallwork B, Coman W, Mackay-Sim A, Greiff L, Cervin A (2006) A double-blind, randomised, placebo-controlled trial of macrolide in the treatment of chronic rhinosinusitis. Laryngoscope 116(2):189-193.
• Burne THJ, Johnston ANB, McGrath JJ, Mackay-Sim A (2006) Swimming behaviour and post-swimming activity in vitamin D receptor knockout mice. Brain Research Bulletin 69(1):74-78.
• Deng C, Gorrie C, Hayward I, Elston B, Venn B, Mackay-Sim A, Waite P ( 2006) Survival and migration of human and rat olfactory ensheathing cells in intact and injured spinal cord. Journal of Neuroscience Research 83:1201-1212.
• Mackay-Sim A, Johnston A, Owen C, Burne THJ (2006) Olfactory ability in the healthy population: reassessing presbyosmia. Chemical Senses 2006 Oct, 31 763-71, Epub 2006 Aug 10
• Hummel T, Kobal G, Gudziol H, Mackay-Sim A (2006) Normative data for the "Sniffin' Sticks" including tests of odor identification, odor discrimination, and olfactory thresholds: An upgrade based on a group of more than 3,000 subjects European Archives of Otorhinolaryngology 2007, Mar 264 (3) 237-43 Epub 2006 Sep 23
• Eyles D, Almeras L, Benech P, Patatian A, Mackay-Sim A, McGrath J, Féron F (Accepted October 2006) Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain. Journal of Steroid Biochemistry and Molecular Biology
• Almeras L, Eyles D, Benech P, Laffite D, Villard C, Patatian A, Boucraut J, Mackay-Sim A, McGrath J, Féron F (2007) Developmental vitamin D deficiency is associated with altered mitochondrial and synaptic function in the adult rat brain. Proteomics (Accepted 05.12.06).
• Cervin A, Wallwork B, Mackay-Sim A, Coman WB, Greiff L (2007) Effects of long-term clarithromycin treatment on lavage-fluid markers of inflammation in chronic rhinosinusitis. Journal of Clinical Otolaryngology and Allied Sciences (submitted).
• Choi EA, Leman S, Venn MK, Mackay-Sim A, Carrive P, Waite P (2007) Therapeutic potential of olfactory ensheathing cells in autonomic dysreflexia (submitted)
• Sülz L, Astorga G, Iturriaga R, Mackay-Sim A, Bacigalupo J (2007) Nitric oxide regulates neurogenesis in olfactory epithelium in vitro. (submitted).
• Sülz L, Astorga G, Iturriaga R, Mackay-Sim A, Bacigalupo J (2007) Nitric oxide inhibition induces differentiation of the olfactory cell line OLF 442. (submitted).
• Murrell W, Wetzig A, Donnellan M, Meedeniya A, Silburn P, Mackay-Sim A (2007) Adult human olfactory stem cell therapy in a rat model of Parkinson's disease: a pilot study. (submitted).
• Haxel BR, Grant L, Mackay-Sim A (2007) Olfactory dysfunction after head injury. (submitted)