Researchers at Griffith University’s Eskitis Institute for Drug Discovery have developed a new technique for discovering natural compounds which could lead to novel therapeutic drugs.
Associate Professor Katherine Andrews from Griffith’s Eskitis Institute for Drug Discovery has joined an international team of researchers working on new drugs to combat deadly parasites.
The Eskitis Institute is leading a renaissance in natural drug discovery
Learn about what Eskitis is, what we study and where we are headed.http://www.griffith.edu.au/__data/assets/video_file/0004/579307/Nature-Bank-Harnessing-Biodiversity.mp4 http://www.griffith.edu.au/__data/assets/image/0005/579389/naturebankintro.jpg What is Nature Bank?
Prof Ron Quinn describes Nature Bank, a unique storehouse of chemical diversity from the natural world.http://www.griffith.edu.au/__data/assets/video_file/0004/579325/Nature-Bank-animation.mp4 http://www.griffith.edu.au/__data/assets/image/0009/579411/naturebankanimation.jpg Where does Nature Bank come from?
Where does Nature Bank come from, and where does it go?http://www.griffith.edu.au/__data/assets/video_file/0005/579308/Queensland-Compound-Library.mp4 http://www.griffith.edu.au/__data/assets/image/0006/579390/qcl.jpg What is the Queensland Compound Library?
The Queensland Compound Library (QCL) is a storehouse of novel chemicals created by Australian chemistry researchers. Ms Moana Simpson, QCL Manager, talks about the QCL and its role in multidisciplinary drug discovery.http://www.griffith.edu.au/__data/assets/video_file/0007/579319/Nuclear-Magnetic-Resonance.mp4 http://www.griffith.edu.au/__data/assets/image/0003/579432/nmr.jpg Nuclear Magnetic Resonance - Unlocking Chemical Structures
Prof Tony Carroll talks about Nuclear Magnetic Resonance (NMR) and how it has greatly accelerated drug discovery and to start to win the numbers game.http://www.griffith.edu.au/__data/assets/video_file/0004/579280/Andrews,-Kathy.mp4 http://www.griffith.edu.au/__data/assets/image/0010/579412/andrews.jpg Taking the Fight to Malaria
Malaria is still a huge health and social burden in the developing world. Assoc Professor Kathy Andrews talks about her research into fighting this devastating disease.http://www.griffith.edu.au/__data/assets/video_file/0005/579281/Avery,-Vicky.mp4 http://www.griffith.edu.au/__data/assets/image/0011/579413/avery.jpg Image-Conscious Biology
Modern biology research requires the use of advanced and automated image collection and analysis techniques. Professor Vicky Avery talks about her research into cancer and infectious disease drug discovery using high content screening.http://www.griffith.edu.au/__data/assets/video_file/0007/579301/Brown,-Chris.mp4 http://www.griffith.edu.au/__data/assets/image/0006/579408/brown.jpg Why do you teach?
Students remain the lifeblood of University research. Assoc Prof Chris Brown talks about his motivation for teaching undergraduate chemistry.http://www.griffith.edu.au/__data/assets/video_file/0003/579315/Carroll,-Tony.mp4 http://www.griffith.edu.au/__data/assets/image/0010/579385/carroll.jpg Discovering New Drugs with the Queensland Museum
Eskitis has partnered with expert taxonomists to build the Nature Bank resource. Professor Tony Carroll talks about a key partnership with the Queensland Museum that has revealed thousands of new marine sponge species.http://www.griffith.edu.au/__data/assets/video_file/0008/579302/Coster,-Mark.mp4 http://www.griffith.edu.au/__data/assets/image/0008/579320/coster.jpg Starving Cancer Cells to Death
Certain compounds attack cancer cells that are starved of nutrients. Assoc Prof Mark Coster talks about his research into pancreatic cancer.http://www.griffith.edu.au/__data/assets/video_file/0006/579282/Crane,-Denis.mp4 http://www.griffith.edu.au/__data/assets/image/0007/579409/crane.jpg Do the Fatty Acid Breakdown
Peroxisomes are crucial cell organs that break down fatty acids. Prof Denis Crane discusses what happens when they go wrong.http://www.griffith.edu.au/__data/assets/video_file/0007/579265/Davis,-Rohan.mp4 http://www.griffith.edu.au/__data/assets/image/0009/579321/davis.jpg Searching for New Compounds in Nature
Fungi in Queensland's rainforest are a rich source of new chemical compounds. Assoc Prof Rohan Davis talks about his research into new compounds that are being tested in human diseases.http://www.griffith.edu.au/__data/assets/video_file/0009/579303/Grkovic,-Tanja.mp4 http://www.griffith.edu.au/__data/assets/image/0011/579386/grkovic.jpg Supercooled Drug Discovery
The Eskitis Institute has industry-standard facilities for NMR to identify structures of new compounds. Dr Tanja Grkovic talks about the capabilities of the Eskitis NMR suite.http://www.griffith.edu.au/__data/assets/video_file/0008/579266/Hofmann,-Andreas.mp4 http://www.griffith.edu.au/__data/assets/image/0010/579322/hofmann.jpg Parasite Proteins in 3D
Crystallography is the study of protein structure. Assoc Prof Andreas Hofmann describes his research in protein structures that could lead to a new vaccine.http://www.griffith.edu.au/__data/assets/video_file/0011/579305/Johnston,-Amy.mp4 http://www.griffith.edu.au/__data/assets/image/0012/579387/johnston.jpg Do You Smell Normal?
Sense of smell changes throughout life and big changes can be an early warning for some neurological conditions. Dr Amy Johnston talks about the Australian Database of Olfactory Capability.http://www.griffith.edu.au/__data/assets/video_file/0005/579317/Kennedy,-Derek.mp4 http://www.griffith.edu.au/__data/assets/image/0005/579416/kennedy.jpg Rewriting the Book on Breast Cancer
Cancer research is moving away from a "one size fits all" approach to therapy, with treatments more tailored to individual patients. Dr Derek Kennedy discusses a recent publication that describes this new regime.http://www.griffith.edu.au/__data/assets/video_file/0008/579284/Lopez,-J-Alejandro.mp4 http://www.griffith.edu.au/__data/assets/image/0006/579417/lopez.jpg Can the Body Fight off Breast Cancer?
Dendritic cells are a crucial part of the immune system. Prof J Alejandro Lopez discusses his work on these cells and how they can fight breast cancer.http://www.griffith.edu.au/__data/assets/video_file/0003/579306/Love,-Chris.mp4 http://www.griffith.edu.au/__data/assets/image/0004/579388/love.jpg Probing Proteins to Unlock Cell Signals
How cells and proteins signal each other is critical in brain development. Dr Chris Love describes his research in cel signalling.http://www.griffith.edu.au/__data/assets/video_file/0009/579285/Mackay-Sim,-Alan.mp4 http://www.griffith.edu.au/__data/assets/image/0007/579418/mackaysim.jpg What is Neuro Bank?
Prof Alan Mackay-Sim describes Neuro Bank, a unique resource of cells isolated form the olfactory system that offer new insights into brain function and dysfunction.http://www.griffith.edu.au/__data/assets/video_file/0010/579286/Mellick,-George.mp4 http://www.griffith.edu.au/__data/assets/image/0008/579410/mellick.jpg The Human Factor in Parkinson's Disease Research
Assoc Prof George Mellick talks about the importance of considering the human element in Parkinson's disease research, and how this is enabled my multidisciplinary research.http://www.griffith.edu.au/__data/assets/video_file/0011/579287/Poulsen,-Sally-Ann.mp4 http://www.griffith.edu.au/__data/assets/image/0008/579419/poulsen.jpg Lighting Up Your DNA
Assoc Prof Sally-Ann Poulsen discusses her research into labelling molecules within cells, a crucial tool in cell biology.http://www.griffith.edu.au/__data/assets/video_file/0006/579309/Quinn,-Ron.mp4 http://www.griffith.edu.au/__data/assets/image/0009/579420/quinn.jpg Ancient Knowledge to Fight Modern Pain
The Eskitis Institute is working with an Aboriginal group in the Kimberleys to develop a pain treatment from a natural remedy. Institute Director Prof Ron Quinn describes this unique partnership.http://www.griffith.edu.au/__data/assets/video_file/0007/579310/St-John,-James.mp4 http://www.griffith.edu.au/__data/assets/image/0005/579452/stjohn.jpg Spice Up Your Brain
Dr James St John talkes about his research into natural products from spices and how they can affect regeneration of the brain following injury.http://www.griffith.edu.au/__data/assets/video_file/0008/579311/Stevenson,-Graeme.mp4 http://www.griffith.edu.au/__data/assets/image/0007/579391/stevenson.jpg So What is CTx?
Dr Graeme Stevenson talks about the Cancer Therapeutics CRC (CTx) partnership that is developing small molecules to inhibit proteins implicated in 1/3 of human cancers.http://www.griffith.edu.au/__data/assets/video_file/0009/579267/Tonissen,-Kathryn.mp4 http://www.griffith.edu.au/__data/assets/image/0010/579421/tonissen.jpg Cancer vs. Oxygen
Thioredoxin is a protein that protects cells from too much oxygen. Assoc Prof Kathryn Tonissen talks about her research on thioredoxin and its role in protecting cancer cells from chemotherapy.http://www.griffith.edu.au/__data/assets/video_file/0008/579392/Watters,-Dianne.mp4 http://www.griffith.edu.au/__data/assets/image/0004/579433/watters.jpg How Much Cell Death is Enough?
Assoc Prof Dianne Watters talks about the crippling disease ataxia telangiectasia, which has features of both neurodegeneration and cancer.http://www.griffith.edu.au/__data/assets/video_file/0010/579376/Weible,-Michael.mp4 http://www.griffith.edu.au/__data/assets/image/0006/579453/weible.jpg How Calcium Affects Adult Neural Stem Cells
Dr Michael Weible talks about his research in the role of calcium in signalling within adult neural stem cells.http://www.griffith.edu.au/__data/assets/video_file/0009/579393/Wood,-Stephen.mp4 http://www.griffith.edu.au/__data/assets/image/0008/579455/wood.jpg Natural Products and Parkinson's Disease
Eskitis scientists are combining Neuro Bank and Nature Bank in the study of Parkinson's disease. Assoc Prof Stephen Wood talks about trying to cure Parkinson's in a petri dish.