Griffith University

Book Chapters

1. Poulsen S.-A.; Vu H. Dynamic combinatorial chemistry and mass spectrometry: a combined strategy for high-performance lead discovery, in Dynamic combinatorial chemistry in drug discovery, bioorganic chemistry and materials science. Ed. Miller, B.L.; Wiley & Sons Publishers, New Jersey; ISBN 978-0-470-09603-1; 2010; pp 201-228.
2. Wilkinson, B. L.; Bornaghi, L. F.; Houston, T. A.; Poulsen, S.-A. Click Chemistry in Carbohydrate Based Drug Development and Glycobiology: An Update, in Glycobiology Research Trends, Eds. Powell, G.; McCabe, O.; Nova Science Publishers, NY. ISBN 1-60692-841-4; 2009; pp. 127-172.
3. Wilkinson B.L.; Bornaghi L.F.; Houston T.A. and Poulsen S.-A. The growing impact of click chemistry in carbohydrate-based drug discovery, in Drug Design Research Trends. Ed. Kaplan, S.P.; Nova Science Publishers, NY. ISBN 1-60021-823-7; 2007; pp 57-102.
4. Poulsen S.-A. and Kruppa G.H. In situ medicinal chemistry: screening by electrospray ionization mass spectrometry, in Fragment-based Drug Discovery: Practical Aspects. Eds. Zartler, E.R. and Shapiro M.J.; Wiley & Sons Publishers, London; ISBN 978-0-470-05813-8; 2008; pp 159-198.

Refereed Journal Articles

1. Salmon, A.J.; Williams, M.; Hofmann, A.; Poulsen, S.-A. Protein crystal structures with ferrocene and ruthenocene-based enzyme inhibitors.Chem. Commun. 2012 48, 2328–2330
2. Moeker, J.; Teruya, K.; Rossit, S.; Wilkinson, B.L.; Lopez, M.; Bornaghi, L.F.; Innocenti, A.; Supuran, C.T.; Poulsen, S.-A. Design and synthesis of thiourea compounds that inhibit transmembrane anchored carbonic anhydrases. Bioorg. Med. Chem. 2012, 20, 2392-2404
3. Lopez, M.; Trajkovic, J.; Bornaghi, L.F.; Innocenti, A.; Vullo, D.; Supuran, C.T.; Poulsen, S.–A. Design, Synthesis and Biological Evaluation of Novel Carbohydrate-based Sulfamates as Carbonic Anhydrase Inhibitors. J. Med. Chem. 2011, 54, 1481-1489.
4. Morris, J. C.; Chiche, J; Grellier, C.; Lopez, M.; Bornaghi, L.F.; Maresca, A.; Supuran, C.T.; Pouysségur, J.; Poulsen, S.-A. Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. J. Med. Chem. 2011, 54, 6905-6918.
5. Lopez, M.; Bornaghi, L.F.; Driguez, H.; Poulsen, S.–A. Synthesis of sulfonamide-bridged glycomimetics. J. Org. Chem. 2011, 76, 2965-2975.
6. Lopez, M.; Vu, H.; Wang, C. K.; Wolf, M.; Groenhof, G.; Innocenti, A.; Supuran, C. T.; Poulsen, S.-A. Promiscuity of Carbonic Anhydrase II. Unexpected Ester Hydrolysis of Carbohydrate-Based Sulfamate Inhibitors. J. Am. Chem. Soc. 2011, 133, 18452-18462
7. Davis, R.A.; Hofmann, A.; Osman, A.; Hall, R.A.; Mühlschlegel, F.A.; Vullo, D.; Innocenti, A.; Supuran, C.T.; Poulsen, S.–A. Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases. J. Med. Chem. 2011, 54, 1682-1692.
8. Salmon, A. J.; Williams, M. L.; Maresca, A.; Supuran, C. T.; Poulsen, S.-A. Synthesis of glycoconjugate carbonic anhydrase inhibitors by ruthenium-catalysed azide-alkyne 1,3-dipolar cycloaddition. Bioorg. Med. Chem. Lett. 2011, 54, 1682-1692.
9. Lopez, M.; Salmon, A.J; Supuran, C.T; Poulsen, S.-A. Carbonic anhydrase inhibitors developed through 'click tailing'. Curr. Pharm. Des. 2010, 29, 3277-3287.
10. Drinkwater, N.; Vu, H.; Lovell, K. M.; Criscione, K. R.; Collins, B. M.; Prisinzano, T. E.; Poulsen, S.-A.; McLeish, M. J.; Grunewald, G. L.; Martin, J. L. Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors. Biochem. J. 2010, 431, 51-61.
11. Lopez, M.; Bornaghi, L.F.; Innocenti, A.; Vullo, D.; Charman, S.A.; Supuran, C.T. Poulsen, S.-A. Sulfonamide linked neoglycoconjugates – a new class of inhibitors for cancer-associated carbonic anhydrases. J. Med. Chem. 2010, 53, 2913-2926.
12. Wilkinson, B.L.; Bornaghi, L.F. Lopez, M.; Healy, P.C.; Poulsen, S.-A.; Houston, T.A. Synthesis of N-Propargyl Azasugar Scaffolds for Compound Library Generation using Click Chemistry. Aust. J. Chem. 2010, 63, 821-829.
13. Davis, R.A.; Innocenti, A.; Poulsen, S.-A.; Supuran, C.T. Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library. Bioorg. Med. Chem. 2010, 18, 14-18.
14. Poulsen, S.-A. Carbonic anhydrase inhibition as a cancer therapy: a review of patent literature 2007-2009. Exp. Opin. Ther. Pat. 2010, 20, 795-806.
15. Lopez, M.; Paul, B.; Hofmann, A.; Morizzi, J. Wu, Q.; Charman, S.A.; Innocenti, A.; Vullo, D.; Supuran, C.T. and Poulsen, S.-A. S-glycosyl primary sulfonamides – A new structural class for selective inhibition of cancer-associated carbonic anhydrases. J. Med. Chem. 2009, 52, 6421-6432.
16. Loughrey, B.T.; Williams, M.L.; Healey, P.C.; Innocenti A.; Vullo D.; Supuran C.T.; Parsons, P.G.; Poulsen S.-A. Novel organometallic cationic ruthenium(II) pentamethylcyclopentadienyl benzenesulfonamide complexes targeted to inhibit carbonic anhydrase. J. Biol. Inorg. Chem. 2009, 14, 935-945.
17. Maresca, A.; Temperini, C.; Vu, H.; Pham, N.B.; Poulsen, S.-A.; Scozzafava, A.; Quinn, R.J.; Supuran, C.T. Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. J. Am. Chem. Soc. 2009, 131, 3057-3062.
18. Lopez, M.; Drillaud, N.; Bornaghi, L.B.; Poulsen, S.-A. Synthesis of S-glycosyl primary sulfonamides. J. Org. Chem. 2009, 74, 2811-2816.
19. Singer, M.; Lopez, M.; Bornaghi L.F.; Innocenti A.; Vullo D.; Supuran C.T.; Poulsen S.-A. Inhibition of carbonic anhydrase isozymes with benzene sulfonamides incorporating thio, sulfinyl and sulfonyl glycoside moieties. Bioorg. Med. Chem. Lett. 2009, 19, 2273-2276.
20. Winum, J.-Y.; Poulsen S.-A.; Supuran C.T.; Therapeutic applications of glycosidic carbonic anhydrase inhibitors. Med. Res. Rev. 2009, 29, 419-435.
21. Poulsen S.-A.; Wilkinson B.L.; Innocenti A.; Vullo D.; Supuran C.T.; Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorganic & Medicinal Chemistry Letters 2008, 18, 4624-4627.
22. Wilkinson B.L.; Innocenti A.; Vullo D.; Supuran C.T.; Poulsen S.-A. Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides. Journal of Medicinal Chemistry 2008, 51, 1945-1953.
23. Bornaghi L.F.; Poulsen S.-A.; Healy, P.C.; White, A.R. N-Cinnamoyl-L-phenylalanine methyl ester. Acta Crystallographica 2008, E64, o139.
24. Wilkinson B.L.; Bornaghi L.F.; Houston T.A.; Innocenti A.; Vullo D.; Supuran C.T.; Poulsen S.-A. Carbonic anhydrase inhibitors: inhibition of isozymes I, II and IX with triazole-linked O-glycosides of benzene sulfonamides. Journal of Medicinal Chemistry 2007, 50, 1651-1657.
    
25. Salmon, A. J.; Williams, M. L.; Innocenti, A.; Vullo, D.; Supuran, C. T.; Poulsen, S.-A. Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety. Bioorganic & Medicinal Chemistry Letters 2007, 17, 5032-5035.
26. Wilkinson, B. L.; Bornaghi, L. F.; Wright, A. D.; Houston, T. A.; Poulsen, S.-A. Anti-mycobacterial activity of a bis-sulfonamide. Bioorganic & Medicinal Chemistry Letters 2007, 17, 1355-1357.
27. Wilkinson, B. L.; Bornaghi, L. F.; Houston, T. A.; Innocenti, A.; Vullo, D.; Supuran, C. T.; Poulsen, S.-A. Carbonic Anhydrase Inhibitors: Inhibition of Isozymes I, II, and IX with Triazole-Linked O-Glycosides of Benzene Sulfonamides. Journal of Medicinal Chemistry 2007, 50, 1651-1657.
28. Wilkinson, B. L.; Bornaghi, L. F.; Houston, T. A.; Innocenti, A.; Vullo, D.; Supuran, C. T.; Poulsen, S.-A. Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides. Bioorganic & Medicinal Chemistry Letters 2007, 17, 987-992.
29. Davis, R. A. H., P.C.; Poulsen, S.-A. N-{2-[4-(Aminosulfonyl)phenyl]ethyl}-2-(4-hydroxyphenyl)acetamide. Acta Cryst. E 2007, E63, o96-o97.
30. Bornaghi, L. F. P., S.-A.; Healy, P.C.; White, A.R. N-Cinnamoyl-L-valine methyl ester. Acta Cryst. E 2007, E63, o44-o46.
31. Wilkinson, B. L. B., L.F.; Houston, T.A.; Poulsen, S.-A.; White, A.R. 4-Hydroxymethyl-1-(2',3',4',6'-tetra-O-acetyl-��-D-glucopyranosyl)-1,2,3-triazole. Acta Cryst. E 2006, E62, o5065-o5067.
32. Wilkinson, B. L.; Bornaghi, L. F.; Poulsen, S.-A.; Houston, T. A. Synthetic utility of glycosyl triazoles in carbohydrate chemistry. Tetrahedron 2006, 62, 8115-8125.
33. Wilkinson, B. L.; Bornaghi, L. F.; Houston, T. A.; Innocenti, A.; Supuran, C. T.; Poulsen, S.-A. A Novel Class of Carbonic Anhydrase Inhibitors: Glycoconjugate Benzene Sulfonamides Prepared by "Click-Tailing". J. Med. Chem. 2006, 49, 6539-6548.
34. Poulsen, S.-A.; Davis, R. A.; Keys, T. G. Screening a natural product-based combinatorial library using FTICR mass spectrometry. Bioorganic & Medicinal Chemistry 2006, 14, 510-515.
35. Poulsen, S.-A.; Bornaghi, L. F. Fragment-based drug discovery of carbonic anhydrase II inhibitors by dynamic combinatorial chemistry utilizing alkene cross metathesis. Bioorganic & Medicinal Chemistry 2006, 14, 3275-3284.
36. Poulsen, S.-A. Direct Screening of a Dynamic Combinatorial Library Using Mass Spectrometry. Journal of the American Society for Mass Spectrometry 2006, 17, 1074-1080.
37. Wilkinson, B. L. B., L.F.; Houston, T.A.; Poulsen, S.-A.; Healy, P.C. Methyl 2,3,4-tri-O-acetyl-1-azido-1-deoxy-b-D-glucopyranuronate at room temperature. Acta Cryst. E 2005, 61, o738-o740.
38. Poulsen, S.-A.; Bornaghi, L. F.; Healy, P. C. Synthesis and structure-activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II. Bioorganic & Medicinal Chemistry Letters 2005, 15, 5429-5433.
39. Poulsen, S.-A.; Bornaghi, L. F. Microwave-accelerated cross-metathesis reactions of N-allyl amino acid substrates. Tetrahedron Letters 2005, 46, 7389-7392.
40. Bornaghi, L. F. P., S.-A.; Healy, P.C. . N-(2-Nitrophenylsulfonyl)glycine methyl ester. Acta Cryst. E 2005, 61, o323-o325.
41. Bornaghi, L. F.; Poulsen, S.-A. Microwave-accelerated Fischer glycosylation. Tetrahedron Letters 2005, 46, 3485-3488.
42. Bornaghi, L. F. P., S.-A.; Healy, P. C. N-Allyl-N-(2-nitrobenzenesulfonyl)-L-leucine methyl ester. Acta Cryst. E 2004, 60, o383-o385.
43. Bornaghi, L. F.; Wilkinson, B. L.; Kiefel, M. J.; Poulsen, S.-A. Synthesis of cyclic oligomers of a modified sugar amino acid utilising dynamic combinatorial chemistry. Tetrahedron Letters 2004, 45, 9281-9284.
44. Poulsen, S.-A. N., C. L.; Healy, P. C. N-Allyl-N-(2-nitrobenzenesulfonyl)-L-phenylalanine methyl ester. Acta Cryst. E 2003, 59, o967-o968.
45. Poulsen, S.-A.; Young, D. J.; Quinn, R. J. High-pressure synthesis of enantiomerically pure C-6 substituted pyrazolo[3,4-d]pyrimidines. Bioorganic & Medicinal Chemistry Letters 2001, 11, 191-193.
46. Poulsen, S.-A. G., P. J.; Cousins, G. R. L.; Sanders, J. K. M. Electrospray fourier transform ion cyclotron resonance mass spectrometry of dynamic combinatorial libraries. Rapid Communications in Mass Spectrometry 2000, 14, 44-48.
47. Poulsen, S.-A.; Watson, A. A.; Fairlie, D. P.; Craik, D. J. Solution Structures in Aqueous SDS Micelles of Two Amyloid [beta] Peptides of A[beta](1-28) Mutated at the [alpha]-Secretase Cleavage Site (K16E, K16F). Journal of Structural Biology 2000, 130, 142-152.
48. Cousins, G. R.; Poulsen, S.-A.; Sanders, J. K. Molecular evolution: dynamic combinatorial libraries, autocatalytic networks and the quest for molecular function. Current Opinion in Chemical Biology 2000, 4, 270-279.
49. Cousins, G. R. L. P., S.-A.; Sanders, J. K. M. . Dynamic combinatorial libraries of pseudo-peptide hydrazone macrocycles. Chemical Communications 1999, 1575-1576.
50. Poulsen, S.-A.; Quinn, R. J. Adenosine receptors: new opportunities for future drugs. Bioorganic & Medicinal Chemistry 1998, 6, 619-641.
51. Poulsen, S.-A. Q., R. J. Synthesis and Structure-Activity Relationship of Pyrazolo[3,4-d]pyrimidines: Potent and Selective Adenosine A1 Receptor Antagonists. Journal of Medicinal Chemistry 1996, 39, 4156-4161.
52. Poulsen, S.-A.; Quin, R. J. Pyrazolo[3,4-d]pyrimidines: C4, C6 substitution leads to adenosine A1 receptor selectivity. Bioorganic & Medicinal Chemistry Letters 1996, 6, 357-360.

Refereed conference papers

1. Houston T.A.; Wilkinson B.L.; Quader S.; Bornaghi L.F.; Boyd S.E.; Poulsen S.-A.; Jenkins, I.D. Attenuating the solubility of carbohydrate-based drugs for improved delivery and targeting. Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007.
2. Wilkinson, B.L.; Bornaghi, L.F.; Poulsen, S.-A; Houston, T.A. In situ click synthesis of glycosyltriazole arylsulfonamides: Hydrophilic carbonic anhydrase II inhibitors. Abstracts of Papers, 231st ACS National Meeting, Atlanta, GA, United States, March 26-30, 2006.