Publications

Book Chapters

  1. Ashman, R. B.; Farah, C. S.; Wells, C. A. In Immunology of Fungal Infection, Brown, G. D. N., M. G, Ed. Springer-Verlag, : London, 2007; pp 131-148.

Refereed Journal Articles

  1. Andrea Bugarcic, Kelly Hitchens, Anthony G. Beckhouse, Christine A. Wells, Robert B. Ashman, and Helen Blanchard, Glycobiology Advance Access published online on May 28, 2008.
  2. Wells CA, Salvage-Jones J, Li X, Hitchens K, Butcher S, Murray R, Beckhouse A, Lo Y, Cobbold C, Ma B, Orr S, Stewart L, Lebus D, Sobieszczuk P, Hume D, Stow, J, Blanchard, H and Ashman, B. The macrophage inducible c-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans. Journal of Immunology 2008 Jun 1;180(11):7404-13.
  3. Hinshelwood RA, Huschtscha LI, Melki J, Stirzaker C, Abdipranoto A, Vissel B, Ravasi T, Wells CA, et al: Concordant epigenetic silencing of transforming growth factor-beta signaling pathway genes occurs early in breast carcinogenesis. Cancer Research 2007, 67(24):11517-11527.
  4. Hume, D. A.; Wells, C. A.; Ravasi, T. Transcriptional regulatory networks in macrophages. Novartis Found Symp 2007, 281, 2-18; discussion 18-24, 50-3, 208-9.
  5. Wells, C. A.; Chalk, A. M.; Forrest, A.; Taylor, D.; Waddell, N.; Schroder, K.; Himes, S. R.; Faulkner, G.; Lo, S.; Kasukawa, T.; Kawaji, H.; Kai, C.; Kawai, J.; Katayama, S.; Carninci, P.; Hayashizaki, Y.; Hume, D. A.; Grimmond, S. M. Alternate transcription of the Toll-like receptor signaling cascade. Genome Biol 2006, 7, R10.
  6. Pham, T. D.; Wells, C. A.; Crane, D. I. Analysis of Microarray Gene Expression Data. Current Bioinformatics 2006, 1.
  7. Maeda, N.; Kasukawa, T.; Oyama, R.; Gough, J.; Frith, M.; Engstrom, P. G.; Lenhard, B.; Aturaliya, R. N.; Batalov, S.; Beisel, K. W.; Bult, C. J.; Fletcher, C. F.; Forrest, A. R.; Furuno, M.; Hill, D.; Itoh, M.; Kanamori-Katayama, M.; Katayama, S.; Katoh, M.; Kawashima, T.; Quackenbush, J.; Ravasi, T.; Ring, B. Z.; Shibata, K.; Sugiura, K.; Takenaka, Y.; Teasdale, R. D.; Wells, C. A.; Zhu, Y.; Kai, C.; Kawai, J.; Hume, D. A.; Carninci, P.; Hayashizaki, Y. Transcript annotation in FANTOM3: mouse gene catalog based on physical cDNAs. PLoS Genet 2006, 2, e62.
  8. Forrest, A. R.; Taylor, D. F.; Crowe, M. L.; Chalk, A. M.; Waddell, N. J.; Kolle, G.; Faulkner, G. J.; Kodzius, R.; Katayama, S.; Wells, C.; Kai, C.; Kawai, J.; Carninci, P.; Hayashizaki, Y.; Grimmond, S. M. Genome-wide review of transcriptional complexity in mouse protein kinases and phosphatases. Genome Biol 2006, 7, R5.
  9. Engstrom, P. G.; Suzuki, H.; Ninomiya, N.; Akalin, A.; Sessa, L.; Lavorgna, G.; Brozzi, A.; Luzi, L.; Tan, S. L.; Yang, L.; Kunarso, G.; Ng, E. L.; Batalov, S.; Wahlestedt, C.; Kai, C.; Kawai, J.; Carninci, P.; Hayashizaki, Y.; Wells, C.; Bajic, V. B.; Orlando, V.; Reid, J. F.; Lenhard, B.; Lipovich, L. Complex Loci in human and mouse genomes. PLoS Genet 2006, 2, e47.
  10. Carninci, P.; Sandelin, A.; Lenhard, B.; Katayama, S.; Shimokawa, K.; Ponjavic, J.; Semple, C. A.; Taylor, M. S.; Engstrom, P. G.; Frith, M. C.; Forrest, A. R.; Alkema, W. B.; Tan, S. L.; Plessy, C.; Kodzius, R.; Ravasi, T.; Kasukawa, T.; Fukuda, S.; Kanamori-Katayama, M.; Kitazume, Y.; Kawaji, H.; Kai, C.; Nakamura, M.; Konno, H.; Nakano, K.; Mottagui-Tabar, S.; Arner, P.; Chesi, A.; Gustincich, S.; Persichetti, F.; Suzuki, H.; Grimmond, S. M.; Wells, C. A.; Orlando, V.; Wahlestedt, C.; Liu, E. T.; Harbers, M.; Kawai, J.; Bajic, V. B.; Hume, D. A.; Hayashizaki, Y. Genome-wide analysis of mammalian promoter architecture and evolution. Nat Genet 2006, 38, 626-35.
  11. Wells, C. A.; Ravasi, T.; Hume, D. A. Inflammation suppressor genes: please switch out all the lights. J Leukoc Biol 2005, 78, 9-13.
  12. Sester, D. P.; Trieu, A.; Brion, K.; Schroder, K.; Ravasi, T.; Robinson, J. A.; McDonald, R. C.; Ripoll, V.; Wells, C. A.; Suzuki, H.; Hayashizaki, Y.; Stacey, K. J.; Hume, D. A.; Sweet, M. J. LPS regulates a set of genes in primary murine macrophages by antagonising CSF-1 action. Immunobiology 2005, 210, 97-107.
  13. Rehli, M.; Sulzbacher, S.; Pape, S.; Ravasi, T.; Wells, C. A.; Heinz, S.; Sollner, L.; El Chartouni, C.; Krause, S. W.; Steingrimsson, E.; Hume, D. A.; Andreesen, R. Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor. J Immunol 2005, 174, 7111-22.
  14. Katayama, S.; Tomaru, Y.; Kasukawa, T.; Waki, K.; Nakanishi, M.; Nakamura, M.; Nishida, H.; Yap, C. C.; Suzuki, M.; Kawai, J.; Suzuki, H.; Carninci, P.; Hayashizaki, Y.; Wells, C.; Frith, M.; Ravasi, T.; Pang, K. C.; Hallinan, J.; Mattick, J.; Hume, D. A.; Lipovich, L.; Batalov, S.; Engstrom, P. G.; Mizuno, Y.; Faghihi, M. A.; Sandelin, A.; Chalk, A. M.; Mottagui-Tabar, S.; Liang, Z.; Lenhard, B.; Wahlestedt, C. Antisense transcription in the mammalian transcriptome. Science 2005, 309, 1564-6.
  15. Cowieson, N. P.; Listwan, P.; Kurz, M.; Aagaard, A.; Ravasi, T.; Wells, C.; Huber, T.; Hume, D. A.; Kobe, B.; Martin, J. L. Pilot studies on the parallel production of soluble mouse proteins in a bacterial expression system. J Struct Funct Genomics 2005, 6, 13-20.
  16. Carninci, P.; Kasukawa, T.; Katayama, S.; Gough, J.; Frith, M. C.; Maeda, N.; Oyama, R.; Ravasi, T.; Lenhard, B.; Wells, C.; Kodzius, R.; Shimokawa, K.; Bajic, V. B.; Brenner, S. E.; Batalov, S.; Forrest, A. R.; Zavolan, M.; Davis, M. J.; Wilming, L. G.; Aidinis, V.; Allen, J. E.; Ambesi-Impiombato, A.; Apweiler, R.; Aturaliya, R. N.; Bailey, T. L.; Bansal, M.; Baxter, L.; Beisel, K. W.; Bersano, T.; Bono, H.; Chalk, A. M.; Chiu, K. P.; Choudhary, V.; Christoffels, A.; Clutterbuck, D. R.; Crowe, M. L.; Dalla, E.; Dalrymple, B. P.; de Bono, B.; Della Gatta, G.; di Bernardo, D.; Down, T.; Engstrom, P.; Fagiolini, M.; Faulkner, G.; Fletcher, C. F.; Fukushima, T.; Furuno, M.; Futaki, S.; Gariboldi, M.; Georgii-Hemming, P.; Gingeras, T. R.; Gojobori, T.; Green, R. E.; Gustincich, S.; Harbers, M.; Hayashi, Y.; Hensch, T. K.; Hirokawa, N.; Hill, D.; Huminiecki, L.; Iacono, M.; Ikeo, K.; Iwama, A.; Ishikawa, T.; Jakt, M.; Kanapin, A.; Katoh, M.; Kawasawa, Y.; Kelso, J.; Kitamura, H.; Kitano, H.; Kollias, G.; Krishnan, S. P.; Kruger, A.; Kummerfeld, S. K.; Kurochkin, I. V.; Lareau, L. F.; Lazarevic, D.; Lipovich, L.; Liu, J.; Liuni, S.; McWilliam, S.; Madan Babu, M.; Madera, M.; Marchionni, L.; Matsuda, H.; Matsuzawa, S.; Miki, H.; Mignone, F.; Miyake, S.; Morris, K.; Mottagui-Tabar, S.; Mulder, N.; Nakano, N.; Nakauchi, H.; Ng, P.; Nilsson, R.; Nishiguchi, S.; Nishikawa, S.; Nori, F.; Ohara, O.; Okazaki, Y.; Orlando, V.; Pang, K. C.; Pavan, W. J.; Pavesi, G.; Pesole, G.; Petrovsky, N.; Piazza, S.; Reed, J.; Reid, J. F.; Ring, B. Z.; Ringwald, M.; Rost, B.; Ruan, Y.; Salzberg, S. L.; Sandelin, A.; Schneider, C.; Schonbach, C.; Sekiguchi, K.; Semple, C. A.; Seno, S.; Sessa, L.; Sheng, Y.; Shibata, Y.; Shimada, H.; Shimada, K.; Silva, D.; Sinclair, B.; Sperling, S.; Stupka, E.; Sugiura, K.; Sultana, R.; Takenaka, Y.; Taki, K.; Tammoja, K.; Tan, S. L.; Tang, S.; Taylor, M. S.; Tegner, J.; Teichmann, S. A.; Ueda, H. R.; van Nimwegen, E.; Verardo, R.; Wei, C. L.; Yagi, K.; Yamanishi, H.; Zabarovsky, E.; Zhu, S.; Zimmer, A.; Hide, W.; Bult, C.; Grimmond, S. M.; Teasdale, R. D.; Liu, E. T.; Brusic, V.; Quackenbush, J.; Wahlestedt, C.; Mattick, J. S.; Hume, D. A.; Kai, C.; Sasaki, D.; Tomaru, Y.; Fukuda, S.; Kanamori-Katayama, M.; Suzuki, M.; Aoki, J.; Arakawa, T.; Iida, J.; Imamura, K.; Itoh, M.; Kato, T.; Kawaji, H.; Kawagashira, N.; Kawashima, T.; Kojima, M.; Kondo, S.; Konno, H.; Nakano, K.; Ninomiya, N.; Nishio, T.; Okada, M.; Plessy, C.; Shibata, K.; Shiraki, T.; Suzuki, S.; Tagami, M.; Waki, K.; Watahiki, A.; Okamura-Oho, Y.; Suzuki, H.; Kawai, J.; Hayashizaki, Y. The transcriptional landscape of the mammalian genome. Science 2005, 309, 1559-63.
  17. Ashman, R.; Farah, C.; Hu, Y.; Li, X.; Wells, C. Genetic Models of candida infection and host resistance. Drug Discovery today: 2005, disease Models 2, 155-159.
  18. Aagaard, A.; Listwan, P.; Cowieson, N.; Huber, T.; Ravasi, T.; Wells, C. A.; Flanagan, J. U.; Kellie, S.; Hume, D. A.; Kobe, B.; Martin, J. L. An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1. Structure 2005, 13, 309-17.
  19. Rastan, S.; Hough, T.; Kierman, A.; Hardisty, R.; Erven, A.; Gray, I. C.; Voeling, S.; Isaacs, A.; Tsai, H.; Strivens, M.; Washbourne, R.; Thornton, C.; Greenaway, S.; Hewitt, M.; McCormick, S.; Selley, R.; Wells, C.; Tymowska-Lalanne, Z.; Roby, P.; Mburu, P.; Rogers, D.; Hagan, J.; Reavill, C.; Davies, K.; Glenister, P.; Fisher, E. M.; Martin, J.; Vizor, L.; Bouzyk, M.; Kelsell, D.; Guenet, J. L.; Steel, K. P.; Sheardown, S.; Spurr, N.; Gray, I.; Peters, J.; Nolan, P. M.; Hunter, A. J.; Brown, S. D. Towards a mutant map of the mouse--new models of neurological, behavioural, deafness, bone, renal and blood disorders. Genetica 2004, 122, 47-9.
  20. Meadows, N. A.; Faulkner, G.; Wells, C.; Ravasi, T.; Hume, D.; Sankar, U.; Hu, R.; Ostrowski, M.; Cassady, A. Novel genes regulated by microphthalmia transcription factor in macrophages and osteoclasts. Journal of Bone and Mineral Research 2004, 19, S413-S413
  21. Wells, C. A.; Ravasi, T.; Sultana, R.; Yagi, K.; Carninci, P.; Bono, H.; Faulkner, G.; Okazaki, Y.; Quackenbush, J.; Hume, D. A.; Lyons, P. A. Continued discovery of transcriptional units expressed in cells of the mouse mononuclear phagocyte lineage. Genome Res 2003, 13, 1360-5.
  22. Wells, C. A.; Ravasi, T.; Faulkner, G. J.; Carninci, P.; Okazaki, Y.; Hayashizaki, Y.; Sweet, M.; Wainwright, B. J.; Hume, D. A. Genetic control of the innate immune response. BMC Immunol 2003, 4, 5.
  23. Holmes, R.; Williamson, C.; Peters, J.; Denny, P.; Wells, C. A comprehensive transcript map of the mouse Gnas imprinted complex. Genome Res 2003, 13, 1410-5.
  24. Carninci, P.; Waki, K.; Shiraki, T.; Konno, H.; Shibata, K.; Itoh, M.; Aizawa, K.; Arakawa, T.; Ishii, Y.; Sasaki, D.; Bono, H.; Kondo, S.; Sugahara, Y.; Saito, R.; Osato, N.; Fukuda, S.; Sato, K.; Watahiki, A.; Hirozane-Kishikawa, T.; Nakamura, M.; Shibata, Y.; Yasunishi, A.; Kikuchi, N.; Yoshiki, A.; Kusakabe, M.; Gustincich, S.; Beisel, K.; Pavan, W.; Aidinis, V.; Nakagawara, A.; Held, W. A.; Iwata, H.; Kono, T.; Nakauchi, H.; Lyons, P.; Wells, C.; Hume, D. A.; Fagiolini, M.; Hensch, T. K.; Brinkmeier, M.; Camper, S.; Hirota, J.; Mombaerts, P.; Muramatsu, M.; Okazaki, Y.; Kawai, J.; Hayashizaki, Y. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res 2003, 13, 1273-89.
  25. Wardrop, S. L.; Wells, C.; Ravasi, T.; Hume, D. A.; Richardson, D. R. Induction of Nramp2 in activated mouse macrophages is dissociated from regulation of the Nramp1, classical inflammatory genes, and genes involved in iron metabolism. J Leukoc Biol 2002, 71, 99-106.
  26. Ravasi, T.; Wells, C.; Forest, A.; Underhill, D. M.; Wainwright, B. J.; Aderem, A.; Grimmond, S.; Hume, D. A. Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes. J Immunol 2002, 168, 44-50.
  27. Okazaki, Y.; Furuno, M.; Kasukawa, T.; Adachi, J.; Bono, H.; Kondo, S.; Nikaido, I.; Osato, N.; Saito, R.; Suzuki, H.; Yamanaka, I.; Kiyosawa, H.; Yagi, K.; Tomaru, Y.; Hasegawa, Y.; Nogami, A.; Schonbach, C.; Gojobori, T.; Baldarelli, R.; Hill, D. P.; Bult, C.; Hume, D. A.; Quackenbush, J.; Schriml, L. M.; Kanapin, A.; Matsuda, H.; Batalov, S.; Beisel, K. W.; Blake, J. A.; Bradt, D.; Brusic, V.; Chothia, C.; Corbani, L. E.; Cousins, S.; Dalla, E.; Dragani, T. A.; Fletcher, C. F.; Forrest, A.; Frazer, K. S.; Gaasterland, T.; Gariboldi, M.; Gissi, C.; Godzik, A.; Gough, J.; Grimmond, S.; Gustincich, S.; Hirokawa, N.; Jackson, I. J.; Jarvis, E. D.; Kanai, A.; Kawaji, H.; Kawasawa, Y.; Kedzierski, R. M.; King, B. L.; Konagaya, A.; Kurochkin, I. V.; Lee, Y.; Lenhard, B.; Lyons, P. A.; Maglott, D. R.; Maltais, L.; Marchionni, L.; McKenzie, L.; Miki, H.; Nagashima, T.; Numata, K.; Okido, T.; Pavan, W. J.; Pertea, G.; Pesole, G.; Petrovsky, N.; Pillai, R.; Pontius, J. U.; Qi, D.; Ramachandran, S.; Ravasi, T.; Reed, J. C.; Reed, D. J.; Reid, J.; Ring, B. Z.; Ringwald, M.; Sandelin, A.; Schneider, C.; Semple, C. A.; Setou, M.; Shimada, K.; Sultana, R.; Takenaka, Y.; Taylor, M. S.; Teasdale, R. D.; Tomita, M.; Verardo, R.; Wagner, L.; Wahlestedt, C.; Wang, Y.; Watanabe, Y.; Wells, C.; Wilming, L. G.; Wynshaw-Boris, A.; Yanagisawa, M.; Yang, I.; Yang, L.; Yuan, Z.; Zavolan, M.; Zhu, Y.; Zimmer, A.; Carninci, P.; Hayatsu, N.; Hirozane-Kishikawa, T.; Konno, H.; Nakamura, M.; Sakazume, N.; Sato, K.; Shiraki, T.; Waki, K.; Kawai, J.; Aizawa, K.; Arakawa, T.; Fukuda, S.; Hara, A.; Hashizume, W.; Imotani, K.; Ishii, Y.; Itoh, M.; Kagawa, I.; Miyazaki, A.; Sakai, K.; Sasaki, D.; Shibata, K.; Shinagawa, A.; Yasunishi, A.; Yoshino, M.; Waterston, R.; Lander, E. S.; Rogers, J.; Birney, E.; Hayashizaki, Y. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature 2002, 420, 563-73.
  28. Hume, D. A.; Ross, I. L.; Himes, S. R.; Sasmono, R. T.; Wells, C. A.; Ravasi, T. The mononuclear phagocyte system revisited. J Leukoc Biol 2002, 72, 621-7.
  29. Wells, C.; Brown, S. D. Genomics meets genetics: towards a mutant map of the mouse. Mamm Genome 2000, 11, 472-7.
  30. Nolan, P. M.; Peters, J.; Vizor, L.; Strivens, M.; Washbourne, R.; Hough, T.; Wells, C.; Glenister, P.; Thornton, C.; Martin, J.; Fisher, E.; Rogers, D.; Hagan, J.; Reavill, C.; Gray, I.; Wood, J.; Spurr, N.; Browne, M.; Rastan, S.; Hunter, J.; Brown, S. D. Implementation of a large-scale ENU mutagenesis program: towards increasing the mouse mutant resource. Mamm Genome 2000, 11, 500-6.
  31. Nolan, P. M.; Peters, J.; Strivens, M.; Rogers, D.; Hagan, J.; Spurr, N.; Gray, I. C.; Vizor, L.; Brooker, D.; Whitehill, E.; Washbourne, R.; Hough, T.; Greenaway, S.; Hewitt, M.; Liu, X.; McCormack, S.; Pickford, K.; Selley, R.; Wells, C.; Tymowska-Lalanne, Z.; Roby, P.; Glenister, P.; Thornton, C.; Thaung, C.; Stevenson, J. A.; Arkell, R.; Mburu, P.; Hardisty, R.; Kiernan, A.; Erven, A.; Steel, K. P.; Voegeling, S.; Guenet, J. L.; Nickols, C.; Sadri, R.; Nasse, M.; Isaacs, A.; Davies, K.; Browne, M.; Fisher, E. M.; Martin, J.; Rastan, S.; Brown, S. D.; Hunter, J. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet 2000, 25, 440-3.
  32. Grimmond, S.; Van Hateren, N.; Siggers, P.; Arkell, R.; Larder, R.; Soares, M. B.; de Fatima Bonaldo, M.; Smith, L.; Tymowska-Lalanne, Z.; Wells, C.; Greenfield, A. Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. Hum Mol Genet 2000, 9, 1553-60.
  33. Bellomo, D.; Headrick, J. P.; Silins, G. U.; Paterson, C. A.; Thomas, P. S.; Gartside, M.; Mould, A.; Cahill, M. M.; Tonks, I. D.; Grimmond, S. M.; Townson, S.; Wells, C.; Little, M.; Cummings, M. C.; Hayward, N. K.; Kay, G. F. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. Circ Res 2000, 86, E29-35.
  34. Peters, J.; Wroe, S. F.; Wells, C. A.; Miller, H. J.; Bodle, D.; Beechey, C. V.; Williamson, C. M.; Kelsey, G. A cluster of oppositely imprinted transcripts at the Gnas locus in the distal imprinting region of mouse chromosome 2. Proc Natl Acad Sci U S A 1999, 96, 3830-5.
  35. Passey, R. J.; Williams, E.; Lichanska, A. M.; Wells, C.; Hu, S.; Geczy, C. L.; Little, M. H.; Hume, D. A. A null mutation in the inflammation-associated S100 protein S100A8 causes early resorption of the mouse embryo. J Immunol 1999, 163, 2209-16.
  36. Williamson, C. M.; Beechey, C. V.; Papworth, D.; Wroe, S. F.; Wells, C. A.; Cobb, L.; Peters, J. Imprinting of distal mouse chromosome 2 is associated with phenotypic anomalies in utero. Genet Res 1998, 72, 255-65.
  37. Little, M.; Wells, C. A clinical overview of WT1 gene mutations. Hum Mutat 1997, 9, 209-25.
  38. Clarkson, R. W.; Chen, C. M.; Harrison, S.; Wells, C.; Muscat, G. E.; Waters, M. J. Early responses of trans-activating factors to growth hormone in preadipocytes: differential regulation of CCAAT enhancer-binding protein-beta (C/EBP beta) and C/EBP delta. Mol Endocrinol 1995, 9, 108-20.
  39. Waters, M. J.; Rowlinson, S. W.; Clarkson, R. W.; Chen, C. M.; Lobie, P. E.; Norstedt, G.; Mertani, H.; Morel, G.; Brinkworth, R.; Wells, C. A.; et al. Signal transduction by the growth hormone receptor. Proc Soc Exp Biol Med 1994, 206, 216-20.
  40. Breier, B. H.; Funk, B.; Surus, A.; Ambler, G. R.; Wells, C. A.; Waters, M. J.; Gluckman, P. D. Characterization of ovine growth hormone (oGH) and ovine placental lactogen (oPL) binding to fetal and adult hepatic tissue in sheep: evidence that oGH and oPL interact with a common receptor. Endocrinology 1994, 135, 919-28.
  41. Baumgartner, J. W.; Wells, C. A.; Chen, C. M.; Waters, M. J. The role of the WSXWS equivalent motif in growth hormone receptor function. J Biol Chem 1994, 269, 29094-101.

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