Griffith University

BPharm, PhD, GCertHigherEd

Lecturer

Contact details for Dr Gary Grant

Responsibilities

• 2018PHM Pharmacology (Convenor)
• 3024PHM Human Pharmacology I (Convenor)
• 3028PHM Human Pharmacology II

Research expertise

• Antibiotic therapy and management of infectious diseases
• High-Performance Liquid Chromatography application to:
  • Therapeutic delivery and monitoring of chemotherapeutic agents (e.g., a-tocopheryl succinate, trimethoprim)
  • Investigating secreted virulence factors (e.g., pyocyanin and homoserine lactones) associated with Pseudomonad spp. Infections
• Quality Use of Medicines application to:
  • Investigating device-associated infections
  • Factors influencing prescribing of antibiotics

Recent research grants

• Davey, A.K., & Grant, G.D. Evaluation of the pharmacokinetics of pyocyanin and 1-hydroxyphenazine. Griffith University Molecular Basis of Disease Program - $10,000.
• Vertullo, C., Grant, G. D., Dukie, S., & Grayson, J. (2011). The comparative chondrocyte toxicities of various antibiotics used in the treatment and prevention of surgical related infections. Pindara Private Hospital.
• Nirthanan, S., Rose'Meyer, R., Lewohol, J., Munn, A., Dukie, S., & Grant, G. D. (2010). Automated electrophysiology for studies on ion channels and receptors to enhance research capability in neurobiology, cardiovascular science and drug discovery. GURIP.
• Hattingh, H. L., Shapland, N., Mamic, J., Maganlal, S., & Grant, G. (2009). Improving the efficacy of teaching in the School of Pharmacy. Griffith University Teaching & Learning Grant - $20,000.

Recent publications

• McDermott, C., Chess-Williams, R., Grant, G.D., Perkins, A.V., McFarland, A.J., Davey, A.K., & Anoopkumar-Dukie, S. (2012). Effects of Pseudomonas aeruginosa virulence factor pyocyanin on human urothelial cell function and viability. Journal of Urology, 187(3), 1087-1093.
• Desbrow, B., Biddulph, C., Devlin, B., Grant, G. D., Anoopkumar-Dukie, S., & Leveritt, M. D. (2012). The effects of different doses of caffeine on endurance cycling time trial performance. Journal of Sports Science, 30(2), 115-120.
• McFarland, A.J., Anoopkumar-Dukie, S., Perkins, A.V., Davey, A.K., & Grant, G.D. (2011). Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine induced toxicity. Archives of Toxicology, 86(2), 275-284.
• Kavanagh, J.J., Grant, G.D., & Anoopkumar-Dukie, S. (2011). Low dosage promethazine and loratadine negatively affect neuromotor function. Clinical Neurophysiology, doi:10.1016/j.clinph.2011.07.046.
• McDermott, C., Chess-Willliams, R., Grant, G.D., Perkins, A.V., McFarland, A.J., Davey, A.K., & Anoopkumar-Dukie, S. (2011). Effects of Pseudomonas aeruginosa virulence factor pyocyanin on urothelial cells in vitro. Journal of Urology, accepted for publication.
• Gloyne, L.S., Grant, G.D., Perkins, A., Powell, K.L., McDermott, C.M., Johnson, P.V. ... & Anoopkumar-Dukie, S. (2011). Pyocyanin-induced toxicity in A549 respiratory cells is causally linked to oxidative stress. Toxicol In Vitro, DOI: 10.1016/j.tiv.2011.05.004.
• Grayson, J.E., Grant, G.D., Dukie, S., & Vertullo, C.J. (2011). The In Vitro elution characteristics of vancomycin from tendons. Clinical Orthopaedics and Related Research, DOI: 10.1007/s11999-011-1768-3.
• Renshaw, G.M.C., Kutek, A., Grant, G.D., & Anoopkumar-Dukie, S. (2011). Forecasting elasmobranch survival following exposure to severe stressors. Comparative Biochemistry & Physiology Part A, doi: 10.1016/j.cbpa.2011.08.001.
• Sun, H-K., Seshadri, M., Lingard, S., Monaghan, W., Faoagali, J., Chan, E. ... & Grant, G. (2011). Antibacterial activity of β-cyclodextrin and 2-hydroxypropyl-β-cyclodextrin trimethoprim complexes. American Journal of Microbiology, (In press).
• Irwin, C., Desbrow, B., Ellis, A., O'Keefe, B., Grant, G., & Leveritt, M. (2011). Caffeine withdrawal and high-intensity endurance cycling performance. Journal of Sports Science, 29(5), 509-515.
• Grant, G. D, Zhang, T. T., Gloyne, L. S., Perkins, A. V., Kiefel, M. J., & Anoopkumar-Dukie, S. (2010). Exogenous pyocyanin alters Pseudomonas aeruginosa susceptibility to Ciprofloxacin. American Journal of Microbiology, 1(1), 9-13.
• Haywood, A., Glass, B., Grant, G. D., & Martina, M. (2005). Isoniazid mixture: stability implications of extemporaneous preparation in practice. Journal of Pharmacy Practice and Research, 35(3), 181-182.
• Kilian, G., Jana, A. K., Grant, G. D., & Milne P. J. (2002). The effects of creatine on the retrogradely perfused isolated rat heart. Journal of Pharmacy and Pharmacology, 54(1), 105-109.
• Jamie, H., Dyason, K., Milne, P. J., Grant, G. D., & Graz C. J. M. (2001). The influence of acetoacetate and butyrate on calcium influx and ATP concentrations in HT-29 cells Pharmazie, 56, 332-336.
• Graz, C. J. M., Grant, G. D., Brauns, S. C., Hunt, A., Jamie, H., & Milne P. J. (2000). Cyclic dipeptides in the induction of maturation for cancer therapy. Journal of Pharmacy and Pharmacology, 52, 75-82.