Uncle Reg Knox grew up on the Toomelah Mission, near Boggabilla just across the border from Goondiwindi. He was one of nine children born to John and Carrie Knox of the Kamiliroi Tribe. Uncle Reg began his working life on western properties and undertook jobs like fencing, shearing and ring-barking and other contract work.
Uncle Reg's interest in art began as a small child, and after success in major art competitions in 1968 and 1970, he undertook formal training at the Queensland College of Art during the 1970s. He then worked in various capacities for the Queensland Government in arts and Aboriginal affairs. Uncle Reg then received a Fellowship Grant through the Australian Arts Board in 1983, and in 1987 was commissioned to create a sculptural carving as a gift for the visiting Pope. In 1990 he presented the 'Mianjin' exhibition at the Queensland University Anthropology Museum. He has continued to exhibit and produce commissions throughout South-east Queensland and interstate.
Uncle Reg's community work has been recognised through the awarding of the Quiet Achievers Award and the Arts Award in 1999 followed by the Logan City Citizen of the Year in 2000 and his induction into Logan's Wall of Acclaim in 2004.
Uncle Reg and his daughter Missy have been engaged in teaching reconciliation and an understanding of Aboriginal culture in local schools and government establishments, including the Logan Hospital. He has been active in a number of Griffith University activities as Logan campus has developed.